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Primary Amebic Meningoencephalitis
Primary Amebic Meningoencephalitis (PAM) is an extremely rare and usually deadly disease caused by infection with a single celled organism (amebae), Naegleria fowleri, which cause inflammation of the lining of the brain and spinal cord. The Naegleria amebae is distributed widely around the world. It is present in soil and in virtually all-natural surface waters such as lakes, ponds and rivers or non-chlorinated pools, discharge or holding basins, and hot springs throughout the world. Warm water temperatures caused by the hot summer months allow the amebae to multiply. Thus, the risk may be greater in very warm and particularly shallow waters. Infection with Naegleria is very rare. However, when it does occur, infection is most common during the dry, summer months, when the air temperature is hot, the water is warm, and water levels are low. The number of infections increases during years characterized by heat waves.
PAM infection occurs when water containing the amebae forcefully enters the nose and sinuses. Once in the nasal passages, the amebae moves to the brain, where it multiplies causing the symptoms associated with infection. PAM cannot be transmitted from person-to-person.
Symptoms associated with PAM include high fever, headache, nausea, vomiting, lack of appetite, stiff neck, seizures, and coma as the condition worsens. Disturbances to taste and smell may also occur. In most cases, victims are described as primarily young, healthy individuals who have actively participated in a recreational water activity three to seven days prior to onset of symptoms
PAM is a severe illness that does not respond to routine treatments. However, in those rare instances where treatment has been successful, it was started very early in the course of illness. Death generally occurs from three to seven days following infection with the organism.
What can be done to prevent PAM?
PAM Fact Sheets and Information:
External PAM Resources:
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