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Oklahoma State Immunization Information System - OSIIS

This section provides information on the Oklahoma State Immunization Information System (OSIIS), which is a statewide immunization registry operated by the Oklahoma State Department of Health, designed to collect and maintain accurate, complete, and current immunization records for Oklahomans of all ages.  OSIIS began operations in 1994 and some clinics do not participate in OSIIS, therefore OSIIS does not contain the immunization records of all Oklahomans.

OSIIS logo

The new Oklahoma State Immunization Information System (OSIIS)
Training opportunities, information and updates will be provided
at this location once they become available.
New OSIIS will require Internet Explorer version 11. 
Click here to update now!

For technical issues related to: computer configuration, OSIIS registration problems, system enhancement requests and password resets:

OSIIS Helpdesk
(405) 271-7200
Monday - Friday
8:30 a.m. to 4:30 p.m

For OSIIS Training questions, send an email to:



Immunization Message Submissions for Meaningful Use

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