The Oklahoma Regional Response System was developed by the Oklahoma Office of Homeland Security (OKOHS) and is presently comprised of more than 60 specialized resources located throughout the State of Oklahoma.  More than $21 million in U.S. Department of Homeland Security (U.S. DHS) grant funding has been used for this project.

The system is comprised of different levels of specialized units capable of responding to chemical, biological, radioactive, nuclear and explosive (CBRNE) incidents; as well as agriculture emergencies, technical rescue incidents and natural disasters.  The Regional Response System units are standardized across the state and are interoperable providing for more effective and efficient training, exercising and response.

Local agencies across Oklahoma agreed to participate in the Regional Response System and entered into an agreement to participate in local, regional and statewide responses to a CBRNE incident or natural disaster.  Each response unit is the property of the participating agency and can be used at any time the local community has a need.  The unit can also be sent to neighboring communities when requested.  Agencies with a unit enlisted responders from surrounding communities and agencies to participate on their response team.  The local community (or state agency) has primary responsibility for the unit including storage; maintenance and replenishment of supplies and ensuring the team members are trained to the required level.