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 Oklahoma State Immunization Information System - OSIIS

This section provides information on the Oklahoma State Immunization Information System (OSIIS), which is a statewide immunization registry operated by the Oklahoma State Department of Health, designed to collect and maintain accurate, complete, and current immunization records for Oklahomans of all ages. Since OSIIS began operations in 1994 and some clinics do not participate in OSIIS, it does not contain the immunization records of all Oklahomans.

Immunization Message Submissions for Meaningful Use

Important Notice for Current OSIIS Users
If you cannot access OSIIS you must submit the following forms:

Business Associate Agreement (309k.pdf) and 
OSIIS Facility Authorization Request Form (41k.pdf) 

Fax or mail both forms to the Immunization Service.  Your site will be reactivated within 2 to 3 business days following receipt of the forms.
The purpose of the Business Associate Agreement is to comply with HIPAA regulations regarding access to and creation of Protected Health Information (PHI) in OSIIS.  

The Immunization Service fax number is: (405) 271-6133.

The mailing address is: 
Immunization Service
Okla. State Dept. of Health
1000 N.E. 10th St.
Okla. City, OK 73117

If you have any questions please call the Immunization Service at (405) 271-7200 or (405) 271-4073.

Log-In to OSIIS

If you already have access to OSIIS, click here to log-in. 

How to Become an OSIIS User

  • To access OSIIS you will need a computer with Internet access and Internet Explorer Version 5.5 or higher.
  • To request access to OSIIS complete these 2 forms and mail them to the Immunization Service at the address:
  • If you have any questions, contact the OSIIS staff at (405) 271-7200.

If you are enrolling in the Oklahoma Vaccines For Children (VFC) Program, STOP, and go to the VFC page and follow the instructions to enroll in the VFC Program and obtain OSIIS access all in one process. 

Important Reminder for OSIIS Account Administrators - Inactivate Former Employees

OSIIS account administrators are urged to periodically review the OSIIS user list for their clinic and inactivate employees who are no longer employed at the clinic or facility.  The user list is located at the bottom of all OSIIS pages when you are logged in as OSIIS Site/Account Administrator.  

Follow these steps to inactivate employees:

  1. Click on the Users List tab at the bottom of the page to pull up a list of your employees who have OSIIS access.
  2. Review the list for names of individuals no longer employed at your facility.  You might want to print this list to use in step 3 if it is a lengthy list or you can simply write down the names of former employees who are still on the Users List
  3. Click on the Manage Users tab at the bottom of the page.  
  4. Select Update Users.
  5. Using the down arrow key, locate a former employee, highlight their name and click on Submit.
  6. When the employee’s information appears on your screen, use the down arrow key to change the Status to Inactive.
  7. Click on the Update button to complete the procedure..

If former employees are not inactivated, they can still gain access to OSIIS through any Internet connection.   
Allowing former employees to retain access to OSIIS is a violation of HIPAA regulations as the former employee no longer has a valid need to access OSIIS records.

If you have any questions please call the Immunization Service at (405) 271-7200.

OSIIS Reference Materials

Explanation of Abbreviations Used for Site & Route for OSIIS Data Entry (30k.pdf)

How OSIIS Works

  • Doctors and clinics record immunizations they have given in OSIIS.
  • All of the immunizations given to an individual are entered into that person's record.
  • When an individual visits a different clinic, that clinic can view the immunizations given previously.
  • OSIIS provides official immunization records for school and childcare entry, camp entry requirements, and any other program that requires an immunization record.
  • Clinics, schools, and childcare facilities can check OSIIS to determine what vaccines an individual has received.
  • Keep in mind that if an individual received immunizations from a clinic that does not use OSIIS, those immunizations will not be recorded in OSIIS.

Benefits of OSIIS

  • Provides a system that can maintain immunization records from many different clinics and doctor’s offices.
  • Generates reminder postcards which are sent to parents when their children are "Due" or "Past Due" for immunizations.
  • Saves parents time going to the doctor’s office or clinic to obtain a copy of their children’s immunization records because many schools can check immunization records online.
  • Helps prevent children, adolescents, and adults from receiving vaccines they have already received.
  • Provides schools and childcare facilities quick easy access to immunization records, even if the child received vaccines at more than one clinic.



Frequently Asked Questions
Q: How can a clinic participate in OSIIS?
A: Clinics can obtain access to OSIIS by completing the Facility Authorization Request Form and Business Associate Agreement Form and fax both documents to the Immunization Service at (405) 271-6133 or mail them to:
Immunization Service
Okla. State Dept. of Health
1000 N.E. 10th St.
Okla. City, 73117

Q: Can schools and childcare centers use OSIIS?
A: Yes, schools and childcare centers can use OSIIS to view children's immunization records.

Interesting Facts
Oklahoma was one of the first states to develop a statewide immunization registry. The Oklahoma State Immunization Information System (OSIIS) began operating in 1994.

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